Week 11 NFL “Monday Night Football” Game Picks and Predictions


Week 11 of the 2022 NFL season is almost over. It couldn’t quite live up to the Week 10 spectacle, with quite a few low scoring matches and a number of blowouts. Atlanta Falcons fans could rejoice, as the team defeated the Chicago Bears to snap a two-game losing streak. We also looked at the Philadelphia Eagles narrowly avoid another upset, this time at the hands of the Indianapolis Coltsand the Dallas Cowboys absolutely dominate the Minnesota Vikings.

This week’s Monday Night Football game once again features a huge lag, at least according to bettors. The San Francisco 49ers take the Arizona Cardinals with Colt McCoy starting at QB and with a number of starters out of the lineup. It looks like a tough place for Arizona, but division games can sometimes be closer than expected.

Let’s get straight into tonight’s picks, which I’ll make based on a straight money line (i.e. picking the winner). I will still provide information on the spread and over/under, for those who are interested. Down below, I’ll show the rest of the staff picks for the game.

All ratings are taken from DraftKings Sportsbook and are subject to change. View current odds here.

Monday Night Football: San Francisco 49ers (5-4) vs. Arizona Cardinals (4-6)

The pick: 49ers -450

Gap: 49ers -10 | Over/Under: 43 | Moneyline: 49ers -450, Cardinals +360

I feel like the 49ers should be better than they are, but outside of beating the Rams twice and dominating the Panthers, San Francisco has just been kind of…good, not great. They will have the opportunity for a decisive game against a division rival on Monday Night Football, as the Arizona Cardinals come to town with a number of crucial players injured. I expect the 49ers to take care of business, even though Colt McCoy is one of the best reserve QBs in the league.

Choice of personnel

What are your picks and predictions for tonight Monday night football matches?

Dimensions/lines subject to change. The T&Cs apply. See draftkings.com/sport bets for more details.


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