Rams vs 49ers odds, spread, line: Monday Night Football picks, NFL model predictions on 139-103 run


An NFC West contest between the Los Angeles Rams (2-1) and San Francisco 49ers (1-2) is taking place on Monday Night Football. After losing its first game of the season, Los Angeles has won two straight games. In Week 3, the Rams defeated the Arizona Cardinals 20-12. On the opposite sideline, San Francisco lost a nail-biter, 11-10 to the Denver Broncos in Week 3.

Kickoff from Levi’s Stadium in Santa Clara, Calif., is scheduled for 8:15 p.m. ET. San Francisco is favored by 1.5 points in Caesars Sportsbook’s latest Rams vs. 49ers odds, and the plus/minus is 42. Before making 49ers vs. Rams picks, you need to check NFL predictions and SportsLine projection model betting tips.

The model, which simulates every NFL game 10,000 times, is up nearly $7,000 for players at $100 on top NFL Picks since its creation. The model enters Week 4 of the 2022 NFL season on an incredible 139-103 run on NFL’s top picks that dates back to the 2017 season.

The model has also ranked in the top 10 on NFLPickWatch four of the last six years on NFL direct picks and has beaten more than 94% of CBS Sports Football Pick’em players four times during that time. Anyone who followed him is upstairs.

Now the model broke on Monday 49ers vs Rams matchup and just locked in his MNF picks and predictions. You can head over to SportsLine now to see the model choices.. here are the NFL odds and betting lines for the Rams vs. the Niners:

  • Difference between the Rams and the 49ers: San Francisco -1.5
  • Rams vs. 49ers over/under: 42 points
  • Money line Rams vs 49ers: Los Angeles +105, San Francisco -125
  • SF: 49ers are 5-0 ATS in their last five home games
  • LAR: Rams are 4-1 ATS in their last five games on Monday
  • Pick Rams vs. 49ers: View SportsLine Picks

Featured game | San Francisco 49ers vs Los Angeles Rams

Why the 49ers can cover

DeMeco Ryans defensive coordinator played this unit at a superb level in the first three weeks of the season. San Francisco is aggressive up front with quick playmakers throughout the secondary and linebackers. The Niners rank second in total yards allowed (227), first in passing yards allowed (148.3) and fourth in rushing yards allowed (78.7). They are also second in points allowed (12.3).

Linebacker Dr. Greenlaw is an athletic, fast-paced force who excels at coverage. Greenlaw has great instincts in both the running and passing game. The Arkansas product leads the team in total tackles (23) with two TFLs. Safety Talanoa Hufanga has also been a force in the box for the 49ers. Hufanga can handle his coverage responsibilities against tight ends while patiently continuing the run. The USC product is second in the club in total tackles (21) with three pass deflections.

Why the Rams can cover

Quarterback Matthew Stafford has a big arm and solid vision on the field. The 34-year-old tends to shoot the pitch with utmost confidence. He completes 72% of throws for 761 yards with four passing touchdowns. In his last outing, he went 18 of 25 for 249 yards with 10 yards per attempt.

Wide receiver Cooper Kupp is a true No. 1 option. Kupp has been an exceptional road runner with the ability to consistently pull apart. The 2021 Pro Bowl selection has an effortless version with excellent agility and a change of direction. The Eastern Washington product ranks second in catches (28), eighth in receiving yards (280) and tied for second in receiving touchdowns (3). In Week 2, he finished with 11 catches for 108 yards and two scores.

How to make Rams vs 49ers picks

The model broke down Niners vs. Rams on Monday Night Football from every angle. He tips Under on the total, throwing a combined 40 points. The model also indicates that one side of the gap hits well over 50% of the time. You can only get model MNF picks on SportsLine.

So who does the 49ers win against the Rams on Monday Night Football? And which side of the spread hits more than 50% of the time? Visit SportsLine now to find out which side of the 49ers vs. Rams spread you should be everywhere on Monday, all from the model on a 139-103 roll on his top-rated NFL picksand find out.


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